Sucralose can safely be consumed by pregnant and lactating mothers, although it is advisable that they consult their doctor before consuming any new product.

Sucralose can also be safely used by children. For children suffering from juvenile diabetes, sucralose is the best way they can enjoy their sweets. Aspartame, another sugar substitute is not intended to be used by children below 6 yrs of age.

People who lack the enzyme to convert phenylalanine to tyrosine are not able to metabolize phenylalanine normally. This condition is called Phenylketonuria, PKU, because excess phenylalanine is instead converted to phenylketones which appear in the urine. If it is not detected and treated, this condition can lead to mental retardation. Sucralose does not contain phenylalanine, thus it can be safely used by population with Phenylketonuria. On the contrary Aspartame contains phenylalanine; hence aspartame is not suitable to be used by PKU patients.

Since Sucralose is not recognized as sugar or a carbohydrate by the body, it has no short term or long term effect on blood glucose control. It is not metabolized by the body and passes rapidly through the body virtually unchanged, therefore leaves no residues in the gastrointestinal tract.

Whereas, prolonged and excessive use of Aspartame can cause fibromyalgia symptoms, migraines, spasms, shooting pains, numbness in legs, cramps, vertigo, dizziness, headaches, tinnitus, joint pain, depression, anxiety attacks, slurred speech, blurred vision or memory loss. Aspartame also causes fluctuation in the blood sugar out of control, thus diabetics may suffer acute memory loss.

Aspartame is digested by the body during which methanol gets converted to formic acid and formaldehyde (a chemical used in embalming). Formaldehyde has its own side effects i.e., it begins to build up in fat cells of the hips and thighs thus leaving its residues inside our body.